Nesiritide not verified

Nesiritide: harmful or harmless?

Nesiritide is the recombinant form of human B-type (brain) natriuretic peptide (BNP), and its amino acid sequence is identical to that of endogenous human BNP. Administration of nesiritide results in venous and arterial vasodilation, as well as enhanced diuresis. Given the many limitations of therapies previously available for the treatment of acute decompensated heart failure, the anticipation...

Nesiritide – Run and hide?

Data extraction: Data were extracted from FDA and sponsor documents and corroborated with published articles when available. Thirty-day survival was assessed by metaanalysis using a fixed-effects model and time-dependent risk by Kaplan-Meier analysis with Cox proportional hazards regression modeling. Where deaths were described within a range of days after treatment, an extreme assumption was m...

Totally Verified Systems: Linking Verified Software to Verified Hardware

Rensch's rule is not verified in melanopline grasshoppers (Acrididae)

Sexual size dimorphism (SSD) is almost universal in animals. Rensch’s rule proposes that SSD increases with increasing average body size in taxa where males are larger than females (malebiased SSD; MBSSD) and decreases when females are larger (femalebiased SSD; FBSSD). Although it was proposed that both patterns are part of the same evolutionary trend, there is more evidence for Rensch’s rule i...

Nesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine

Background—Nesiritide (synthetic human brain natriuretic peptide) is approved for the treatment of symptomatic heart failure. However, studies of brain natriuretic peptide in patients with heart failure have come to conflicting conclusions about effects on glomerular filtration rate (GFR), effective renal plasma flow, natriuresis, and diuresis. Methods and Results—To identify a population at hi...